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Acetylfentanyl for sale (2-methyl-MAF) is an analytical reference material as an opioid (2-ME-MAF for sale online). Regulation of Acetyl fentanyl is as a Schedule I compound in the United States. Professionals use this product for research and forensic applications.Buy Acetylfentanyl Powder Online Without Prescription. Order Acetyl fentanyl HCL Online Without Prescription. Acetylfentanyl Powder (acetyl fentanyl) is a relative of a powerful prescription painkiller called fentanyl and is five times more potent than heroin as a painkiller, according to the Centers for Disease Control and Prevention.
Acetyl fentanyl is an opioid painkiller and an analog of the drug fentanyl. An analog drug is designed to function in a manner similar to the original drug. However, the chemical makeup is slightly different. Analog drugs are created to avoid detection on toxicology tests, as well as the legal ramifications associated with the parent drug.
How is acetylfentanyl an analog of fentanyl? As an analog of fentanyl, acetylfentanyl is a Schedule I controlled drug. As of October, 2015 acetylfentanyl is a controlled substance in China. Acetylfentanyl is a Schedule I controlled substance as of May 2015. Acetylfentanyl is illegal in Switzerland as of December 2015. Acetylfentanyl was made a class A drug as an analogue of fentanyl in 1986.
When was acetylfentanyl made a Class A drug? Acetylfentanyl was made a class A drug as an analogue of fentanyl in 1986. Acetylfentanyl overdosage has been reported to closely resemble heroin overdosage clinically. Additionally, while naloxone (Narcan) is effective in treating acetylfentanyl overdose, larger than normal doses of the antidote may be required.
Is there a medical use for acetylfentanyl? It has never been licensed for medical use and instead has only been sold as a designer drug. Acetylfentanyl was discovered at the same time as fentanyl itself and had only rarely been encountered on the illicit market in the late 1980s. However, in 2013, Canadian police seized 3 kilograms of acetylfentanyl.
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Nausea is a diffuse sensation of unease and discomfort, often perceived as an urge to vomit. While not painful, it can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, upper abdomen, or back of the throat.Over 30 definitions of nausea were proposed in a 2011 book on the topic.
Nausea is a non-specific symptom, which means that it has many possible causes. Some common causes of nausea are gastroenteritis and other gastrointestinal disorders, food poisoning, motion sickness, dizziness, migraine, fainting, low blood sugar and lack of sleep. Nausea is a side effect of many medications including chemotherapy, or morning sickness in early pregnancy. Nausea may also be caused by disgust and depression. Medications taken to prevent and treat nausea are called antiemetics. The most commonly prescribed antiemetics in the US are promethazine, metoclopramide and the newer, extremely effective ondansetron. The word nausea is from Latin nausea.
Taking a thorough patient history may reveal important clues to the cause of nausea and vomiting. If the patient’s symptoms have an acute onset, then drugs, toxins, and infections are likely. In contrast, a long-standing history of nausea will point towards a chronic illness as the culprit. The timing of nausea and vomiting after eating food is an important factor to pay attention to. Symptoms that occur within an hour of eating may indicate an obstruction proximal to the small intestine, such as gastroparesis or pyloric stenosis. An obstruction further down in the intestine or colon will cause delayed vomiting. An infectious cause of nausea and vomiting such as gastroenteritis may present several hours to days after the food was ingested.
The contents of the emesis is a valuable clue towards determining the cause. Bits of fecal matter in the emesis indicate obstruction in the distal intestine or the colon. Emesis that is of a bilious nature (greenish in color) localizes the obstruction to a point past the stomach. Emesis of undigested food points to an obstruction prior to the gastric outlet, such as achalasia or Zenker’s diverticulum. If patient experiences reduced abdominal pain after vomiting, then obstruction is a likely etiology. However, vomiting does not relieve the pain brought on by pancreatitis or cholecystitis.
The United States has a prescription drug problem. About 52 million Americans have misused prescription medications for non-medical purposes, reported from the National Institute on Drug Abuse (NIDA).
Prescription painkiller abuse, especially of the opiate class, can be especially devastating for young people as early misuse increases the risk for a lifetime of addiction and dependence. In 2010, one in 20 high school seniors said they abused OxyContin, a type of opiate made from oxycodone. This high abuse rate makes opiates one of the most commonly abused drugs by young people.
In the early stages of drug abuse, many people take OxyContin and other opiates by mouth. Consistent drug use causes the body to grow tolerant to the effects of opiates, so the individual must take an ever-stronger dosage to get high. At some point, the drug abuser stops getting high from OxyContin pills so he may choose to inject the drug.
Drug abusers crushed OxyContin before dissolving the pills in a solution to create a form that can be injected or snorted. Injecting OxyContin delivers the active ingredient directly into the bloodstream to cause an immediate high. Snorting OxyContin is not as fast as injecting but quicker than taking a pill.
The FDA approved the original OxyContin formula in 1995. Abuse of the drug began almost immediately. Abusers quickly learned how to convert the drug’s extended-release properties into a more powerful high. This type of manipulation causes a faster release of the active ingredient, oxycodone. Rapid opiate release drastically increases both the buzz and the risk for severe effects, including overdose and death.
To address the problem, the U.S. Food and Drug Administration (FDA) pressed drug manufacturers to create opiates that are more difficult to abuse. The FDA approved a reformulated version of OxyContin in the spring of 2010. This new formula is more difficult to manipulate than the original formula. Purdue Pharma, the manufacturer of OxyContin stopped sending the original formula to pharmacies later that year.
As officials hoped, the number of OxyContin overdose deaths declined sharply after reformulation. One study showed reports of death dropped 82 percent from the year before formulation and three years afterwards.
OxyContin Reformulation
Reformulating OxyContin has produced some unwanted effects. Patients who use OxyContin to control pain were anxious about the effectiveness of the new formula. People who became physically dependent on or addicted to OxyContin were extremely distressed about controlling withdrawal symptoms and cravings after reformulation. Many addicted and dependent people continued to inject the newly reformulated OxyContin at the risk of suffering acute harm. Swelling, pain, and infection may occur at the injection site. Worse still, injecting OxyContin may cause overdose and death.
Other addicted and dependent people switched to heroin and other opiate drugs. Washington University School of Medicine performed a survey of drug abuse patients, asking which opiate they used to get high at least one in the previous 30 days. OxyContin fell from 47.4 percent of respondents before reformulation to 30 percent afterward. The use of heroin nearly doubled during that same period.
Abuse of prescription opiates has skyrocketed too. Unlike the tamper-resistant OxyContin, abusers can still crush and snort or inject prescription opiates like Zohydro, and are doing so at alarming rates. Hospitals around the country report high numbers of opiate overdoses and deaths resulting from drugs other than oxycodone OxyContin.
The FDA recently approved the use of OxyContin for kids, making it the first opioid-based painkiller approved for juvenile patients. The only other painkiller that is currently approved for use in children is the duragesic patch, also called fentanyl, which passes opioids through the skin. While some are applauding the FDA’s efforts at eliminating pain in this younger age group, others are questioning whether prescribing OxyContin to such young children will cause an explosion of addictions.
Restrictions on OxyContin for Kids
With the FDA’s approval of OxyContin for kids comes a set of limitations specifically for treating children with this powerful painkiller. For one, doctors can only prescribe it to children who are between the ages of 11 and 16. The FDA hasn’t approved it for use in those under the age of 11. Additionally, physicians can only prescribe OxyContin to children who have shown a tolerance to 20 milligrams of oxycodone, which is the active ingredient in OxyContin.
OxyContin Benefits
The FDA’s stance comes from the relatively few pain relieving options that are currently available to children. Specifically, the intent of approving OxyContin for kids was to provide pain relief options for children suffering from cancer, trauma or who are recovering from major surgery. They have called for physicians to only prescribe it to children who require constant around–the-clock pain relief.
While there is little doubt that the new prescribing regulations will benefit young cancer patients suffering from debilitating pain, concerns abound for children in other illness categories. One of the major concerns with prescribing OxyContin for kids is with regards to dosing. As very few painkillers are approved for use in children, physicians have had to estimate the proper dosage for them based on the current levels used for adults.
Addiction Risks
Another major concern with prescribing OxyContin for kids is with regards to the massive number of adult addiction issues and overdoses that have been attributed to opiate-based painkillers in the last 10 years. In fact, the FDA removed the original formulation of OxyContin off of the market soon after its release due to its highly addictive nature. The drug company reformulated it again in 2010 to make it harder to crush, snort or inject as many abusers tend to do.
Given the past problems with curbing the addiction problem, questions have arisen as to how the medical community plans to prevent these same issues from occurring in children. This is particularly concerning because of the fact that children’s understanding of consequences in general has not yet fully developed. Prescribing them an opiate will act as a numbing device to ease social pressures, fears and insecurities. Thus, it is easy to postulate that unless they highly regulate OxyContin prescriptions, children will flock to the drug in droves as a legal way to eliminate emotional pain as well as physical pain. In fact, studies show that about one in every 25 high school seniors has already abused OxyContin at some point.
The Waismann Method ® physicians do understand the medical need to alleviate pain in children, just as we fully support the elimination of pain in adults. However, we urge the FDA and other medical regulatory agencies to enact very strict rules to protect our children from the life threatening harm that these drugs can pose. Specifically, the FDA should appoint an advisory panel to re-examine the risks and benefits of prescribing OxyContin for kids. Additionally, the FDA should impse strict prescribing regulations for adolescent OxyContin use to prevent addiction and other harmful side effects from occurring in children.
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